Chronic Lymphocytic Leukemia. Increased number of small, well-differentiated lymphocytes. Note “smudge cells.”
Acute Lymphoblastic Leukemia Round or convoluted nuclei, absence of cytoplasmic granules, and high nuclear to cytoplasmic ratio. (Courtesy of Dr. D. Sutton).
(Lymph Node) Reed-Sternberg cell (arrow) is large and bilobed or binucleate. Prominent within the mirror-image nuclei are giant inclusion-like nucleoli (“owl’s eyes”).
Chronic Myelogenous Leukemia Increased numbers of granulocytes and their precursors. Note most WBCs are band forms of segmented granulocytes.
Basophilic stippling are inclusions of aggregated ribosomes. They are a non-specific finding that can indicate regenerative anemias, such as lead poisoning and thalassemia among others.
