Hematologic Malignancies

Note Rouleaux

Acute Myelogenous Leukemia. Note blast cell with Auer rod.

Tear drop RBCs (poikilocytes) in the centre field. (Courtesy of Dr. D. Sutton)

(Bone Marrow)
Plasma cells in marrow. Note Binucleate malignant plasma cell.

Chronic Lymphocytic Leukemia. Increased number of small, well-differentiated lymphocytes. Note “smudge cells.”

Acute Lymphoblastic Leukemia
Round or convoluted nuclei, absence of cytoplasmic granules, and high nuclear to cytoplasmic ratio. (Courtesy of Dr. D. Sutton).

(Lymph Node)
Reed-Sternberg cell (arrow) is large and bilobed or binucleate. Prominent within the mirror-image nuclei are giant inclusion-like nucleoli (“owl’s eyes”).

Chronic Myelogenous Leukemia
Increased numbers of granulocytes and their precursors. Note most WBCs are band forms of segmented granulocytes.